El grupo del Instituto de Biotecnología y Biomedicina de la UAB (UAB-1) ha creado herramientas de análisis de expresión génica masiva en peces gracias a la colaboración con otros participantes de la red. A raíz de estas colaboraciones se han llevado a cabo diseños de nanosistemas delivery de vacunas DNA para peces. Además, el grupo es especialista en el funcionamiento del sistema innato de peces con interés comercial.
2009. Screening for coping style increases the power of gene expression studies. PLoS ONE 4(4): e5314. MacKenzie S, Ribas L, Pilarczyk M, Capdevila DM, Kadri S, Huntingford FA.
2010. Peptidoglycan, not endotoxin, is the key mediator of cytokine gene expression induced in trout macrophages by crude LPS. Molecular Immunol 47(7-8): 1450-57. MacKenzie S, Roher N, Boltana S, Goetz F.
2011. PAMPs, PRRs and the genomics of gram negative bacterial recognition in fish. Dev Comp Immunol 35: 1195-203. Boltaña S, Roher N, Goetz FW, Mackenzie SA.
2011. Is there a direct role for erythrocytes in the immune response? Vet Res 42: 89. Morera R, Mackenzie S.
2011. RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS ONE 6(10): e26998. Morera D, Roher N, Ribas L, Balasch JC, Doñate C, Callol A, Boltaña S, Roberts S, Goetz G, Goetz FW, MacKenzie SA.
2011. Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory out come in trout, Oncorhynchus mykiss, macrophages. BMC Genomics 12: 34. Boltaña S, Reyes-Lopez F, Morera D, Goetz F, MacKenzie SA.
2012. Tumor Necrosis Factor Alpha may act as an intra-ovarian mediator of luteinizing hormone-induced oocyte maturation in trout. Biol Reprod 86: 1-12. Crespo D, Mañanós El, Roher N, Mackenzie S, Planas Jv.
2012. Effects of chronic cortisol administration on global expression of GR and the liver transcriptome in Sparus aurata. Mar Biotechnol 15: 104–14. Teles M, Boltaña S, Reyes-López F, Santos MA, Mackenzie S, Tort L.
2013. Behavioural fever is a synergic signal amplifying the innate immune response. Proc Royal Soc B BiolSciences 280. Boltaña S, Rey S, Roher N, Vargas R, Huerta M, Huntingford FA, Goetz FW, Moore J, Garcia-Valtanen P, Estepa A, MacKenzie S.
2013. Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function. Mol Ecol 22: 6100-15. Rey S, Boltana S, Vargas R, Roher N, Mackenzie S.
2013. Effects of chronic cortisol administration on global expression of GR and the liver transcriptome in Sparus aurata. Marine Biotechnol 15: 104-14. Teles M, Boltaña S, Reyes-López F, Santos MA, Mackenzie S, Tort L.
2013. A novel liposome-based nano carrier loaded with an LPS-dsRNA cocktail for fish innate immune system stimulation. PLoS ONE 8(10): e76338.Ruyra A, Cano MA, Mackenzie SA, Maspoch D, Roher N.
2013. Characterization of PAMP/PRR interactions in European eel (Anguilla anguilla) macrophage-like primary cell cultures. Fish Shellfish Immunol 35: 1216-23. Callol A, Roher N, Amaro C, MacKenzie S.
2013. Abundance of the quorum-qensing Factor Ax21 in four strains of Stenotrophomonas altophilia correlates with mortality rate in a new zebrafish model of infection. PLoS ONE 8(6): e67207. Ferrer-Navarro M, Planell R, Yero D, Mongiardini E, Torrent G, Huedo P, Martínez P, Roher N, Mackenzie S, Gibert I, Daura X.
2014. Nanoparticles as a novel delivery system for Vitamin C administration in aquaculture. Aquaculture 432: 426–33. Jiménez-Fernández E, Ruyra A, Roher N, Zuasti E, Infante C, Fernández-Díaz C.
2014. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy 10: 1666-80. Garcia-Valtanen P, Ortega-Villaizan MM, Martinez-Lopez A, Medina-Gali R, Perez L, Mackenzie S, Figueras A, Coll JM, Estepa A.
2014. Transcriptome profiles associated to VHSV infection or DNA vaccination in turbot (Scophthalmus maximus). PLoSOne 9(8): e104509. Pereiro P, Dios S, Boltaña S, Coll J, Estepa A, Mackenzie S, Novoa B, Figueras A.
2014. The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio). Zebrafish 11(5): 421-33. Dios S, Balseiro P, Costa MM, Romero A, Boltaña S, Roher N, Mackenzie S, Figueras A, Novoa B.
2014. Lipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead sea bream). Fish Shellfish Immunol 39(2): 475-82. Boltaña S, Tridico RM, Teles M, Mackenzie S, Tort L.
2015. In vivo molecular responses of fast and slow muscle fibers to lipopolysaccharide in a teleost fish, the rainbow trout (Oncorhynchus mykiss). Biology 4: 67-87. Magnoni LJ, Roher N, Crespo D, Krasnov A, Planas JV.
2015. Zebrafish liver (ZFL) cells are able to mountan anti-viral response after stimulation with Poly (I:C). Comp Biochem Physiol 182: 55-63. Ruyra A, Torrealba D, Morera D, Tort L, MacKenzie S, Roher N.
2015. Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV). Develop. & Comp. Immunol. 53:210-221. Reyes-López FE, Romeo JS, Vallejos-Vidal E, Reyes-Cerpa S, Sandino AM, Vidal R, Tort L, Mackenzie S, Imarai M.
2010. Genomic approaches in aquaculture and fisheries. In: Introduction to Marine Genomics, editedbyCock JM, Tessmar-Raible K, Boyen C and Viard F: Springer, 2010, p. 401.Cancela ML, Bargelloni L, Boudry P, Boulo V, Dias J, Huvet A, Laizé V, Lapège S, Leite R, Mira S, Nielsen EE, Planas JV, Roher N, Sarropoulou E, and Volkaert FAM.
2012. Isolation and culture of fish head kidney mononuclear phagocytes and muscles at elite cells and their use in aquaculture-related research. En: Aquaculture Biotechnology. Fletcher, G. and Rise, M., Editors. Blackwell Publishing. Goetz FW, Planas JV, Mackenzie S.
2009. Biological activity of tumor necrosis factor (TNFalpha) on glucose uptake and gene expression in rainbow trout (Oncorhynchus mykiss). Genomics in Aquaculture, GIA 2009. Bodo, Noruega. 1-5 de septiembre. Vraskou Y, Crespo D, Roher N, Krasnov A, Planas JV.
2009. Analysis of the gonadal transcriptome during sex determination, sex differentiation and gonadal maturation in the sea bass (Dicentrarchus labrax) and turbot (Scophthalmus maximus) by 454 sequencing and two specific oligo-based microarrays. Fourth HCSNet Next-Generation Search Technology Workshop. Sidney, Australia. Abril. Ribas L., Crespo B., Gómez A., Pardo B. G., Reinhardt R., MacKenzie S., Martínez P., Zanuy S. y Piferrer F.
2009. Combined effects of copper and bacterial lipopolysaccharide on immune and oxidative stress responses in rainbow trout macrophages. 11th International congress of the international society for developmental and comparative immunology. Prague (República Checa), 28 Junio-4 Julio. Teles M, Boltaña S, Mackenzie S, Tort L.
2009. Molecular and genomic responses to immune challenges in fish. World Aquaculture 2009. Veracruz, México. Septiembre. Tort L, Doñate C, Balasch JC, Roher N, Mackenzie S.
2009. Analysis of the gonadal transcriptome during sex determination, sex differentiation and gonadal maturation in the sea bass (Dicentrarchus labrax) and turbot (Scophthalmus maximus) by 454 sequencing and two specific oligo-based microarrays. Next Generation Sequencing 2009 International Meeting. Barcelona, 1-3 Octubre. Ribas L., Crespo B, Díaz N, Gómez A, Pardo B, Reinhardt R, MacKenzie S, Martínez P, Zanuy S, Piferrer F.
2009. Biological activity of tumor necrosis factor (TNFalpha) on glucose uptake and gene expression in rainbow trout (Oncorhynchus mykiss). Genomics in Aquaculture, GIA 2009. Bodo, Noruega. 1-5 de Septiembre. Vraskou Y, Crespo D, Roher N, Krasnov A, Planas JV.
2010. Transcriptomic and inflammatory response of cell-wall Peptidoglycan from gram-negative bacteria over fish macrophages. EOFFI meeting. Viterbo Italia. Boltaña S, Roher N, Tort L, Mackenzie S.
2010. Differential isoform expression after crowding plus pathogenic challenge in gilthead sea bream Sparus aurata and in European sea bass Dicentrarchus labrax. Fish Biology Congress. American Fisheries Society. Barcelona. Mauri I, Roher N, MacKenzie S, Tort L.
2010. Expression of glucocorticoid receptor gene in different tissues of sea bream and its relationship with classical physiological response to chronic stressors. Fish Biology Congress. American Fisheries Society. Barcelona. Teles M, Boltaña S, Pacheco M, Santos MA, Mackenzie S, Tort L.
2010. Cloning of C3 in gilthead sea bream (Sparus aurata) and in European sea bass (Dicentrarchus labrax) and its differential expression after crowding plus pathogenic challenge. First EOFFI symposium. Viterbo (Italia), 23-27 Mayo. Mauri I, Roher N, Romero A, Béjar J, Álvarez MC, Mackenzie S, Tort L.
2010. Improvement of aquaculture production by the use of biotechnological tools (AQUAGENOMICS). Aquaculture Europe 2010. Porto (Portugal), 5-8 Octubre. Novoa B, Martínez P, Piferrer F, Mackenzie S, Planas JV, Morán F, Toranzo AE, Mulero V, Sanchez FJ, Estepa A, Coll J, Tort L, Yufera M, Pérez J, Zanuy S, Cerdá JM, Toro MA, Rejón MR, Figueras A.
2012. Stress and Immune response in sea bream (Sparus aurata) after experimental treatment with LPS of A. salmonicida and L. anguillarum. 10th International Congress on the Biology of fish. American Fisheries Soc. Physiology section. Madison, WI, USA 15-19 July. Tridico R, Boltaña S, Fierro-Castro C, Teles M, Cortes R, MacKenzie S, Tort L.
2012. Stress and immune response in sea bream (Sparus aurata) after experimental treatment with LPS of A. salmonicida and L. anguillarum. International Congress on Global Advances on Advanced Biology. Barcelona 9-12 Julio. Tridico R, Boltaña S, Fierro-Castro C, Teles M, Cortes R, MacKenzie S, Tort L.
2013. II Workshop in Nanomedicine de la UAB (8 de Octubre 2013- Hotel Campus UAB (Cerdanyola del Valles). Roher N, Tort L.
2013. Use of an immune-specific microarray for identifying transcriptome profiles associated to the infection of VHSV or to the protection mechanisms induced by a DNA vaccine encoding the G glycoprotein in turbot (Scophthalmus maximus). First International Conference of Fish and Shellfish Immunology (ISFSI). Vigo (España), 25-28 Junio. Pereiro P, Boltaña S, Dios S, Coll J, Estepa A, Mackenzie S, Novoa B, Figueras A.
2013. Zebrafish differential transcriptomic profiles induced by VHSV and SVCV G glycoproteins after genetic immunization. First International Conference of Fish and Shellfish Immunology (ISFSI). Vigo (España), 25-28 Junio. García-Valtanen P, Martínez-López A Ortega-Villaizán M, Cheikh SI, Pérez L, Coll J, Mackenzie S, Figueras A, Estepa A.
2011. Sebastián Boltaña Harms. Universidad Autónoma de Barcelona. Molecular characterization of the under lying mechanisms of pathogen-associated molecular pattern (PAMP) recognition in fish. Directores Mackenzie S, Tort L. Directores Mackenzie S; Tort L.
2012. Israel Mauri Baños. Universidad Autónoma de Barcelona. Isra stocked and locked. Effects of intensive aquaculture practices on immune system of gilthead sea bream (Sparus aurata) and European sea bass (Dicentrarchus labrax). Directores Tort L, Roher N.
2013. Reynaldo Vargas Vargas. Contribución de la personalidad en la variación fenotípica y su impacto sobre la biología del pez cebra Danio rerio. Directores Rey S, Mackenzie S.
Acuerdo contractual con SKRETTING, compañía líder mundial en la producción de dieta para peces. El acuerdo explora tecnologías de cribado desarrolladas en cultivos primarios de macrófagos de peces. El objetivo consistió en seleccionar nuevos compuestos immunoestimulantes para el desarrollo de las dietas.
SKRETTING (Norway): Producción de alimentos e inmunoestimulación a través de la dieta.