Nutrigenomics and Endocrinology of the Fish Growth Group-CSIC

Acronym
IATS-1
Area
Nutrition and Growth Area
Description

The main aim of the Nutrigenomics and Endocrinology group of fish growth was to develop new genomic resources to identify and characterize new biomarkers with predictive value for the re-definition of nutritional requirements of cultured marine fish, with special emphasis on sea bream and sea bass. This was based on the study of growth, susceptibility to stress and resistance to diseases, considering also its effects on fish quality as well as on food safety. To this end, the development of predictive models of fillet fatty acid composition has been considered, as well as a large scale screening of conventional and emerging biocontaminants both on the diet and on the animal itself.

Principal investigator
Other members
Dra. A Sitjá
Dr. J Calduch
Dr. O Palenzuela
Papers SCI

2009. Dynamics of liver GH/IGF axis and selected stress markers in juvenile gilthead sea bream (Sparus aurata) exposed to acute confinement: differential stress response of growth hormone receptors. Comp Biochem Physiol A Mol Integr Physiol 154: 197-203. Saera-Vila A, Calduch-Giner JA, Prunet P, Pérez-Sánchez J.

 

2009. Assessment of the health and antioxidant trade-off in gilthead sea bream (Sparus aurata) fed alternative diets with low levels of contaminants. Aquaculture 296: 87-95. Saera-Vila A, Benedito-Palos L, Sitja-Bobadilla A, Nacher-Mestre J, Serrano R, Kaushik S, Pérez-Sánchez J.

 

2009. Targets for TNF alpha-induced lipolysis in gilthead sea bream (Sparus aurata L.) adipocytes isolated from lean and fat juvenile fish. J Exp Biol 212: 2254-60. Cruz-Garcia L, Saera-Vila A, Navarro I, Calduch-Giner J, Pérez-Sánchez J.

 

2010. Gene expression survey of mitochondrial uncoupling proteins (UCP1/UCP3) in gilthead sea bream (Sparus aurata L.) J Comp Physiol B 180: 685-94. Bermejo-Nogales A, Calduch-Giner JA, Pérez-Sánchez J.

 

2010. Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.) BMC Genomics 11: 193. Calduch-Giner JA, Davey G, Saera-Vila A, Houeix B, Talbot A, Prunet P, Cairns MT, Pérez-Sánchez J.

 

2011. Feed restriction up-regulates uncoupling protein 3 (UCP3) gene expression in heart and red muscle tissues of gilthead sea bream (Sparus aurata L.) New insights in substrate oxidation and energy expenditure. Comp Biochem Physiol A 159: 296-302. Bermejo-Nogales A, Benedito-Palos L, Calduch-Giner JA, Pérez-Sánchez J.

 

2011. Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors. Fish Shellfish Immunol 31: 294-302. Pérez-Sánchez J, Bermejo-Nogales A, Calduch-Giner JA, Kaushik S, Sitjà-Bobadilla A.

 

2012. Modulation of the IgM gene expression and IgM immunoreactivity cell distribution by the nutritional background in gilthead sea bream (Sparus aurata) challenged with Enteromyxum leei (Myxozoa). Fish Shellfish Immunol 33: 401-10. Estensoro I, Calduch-Giner JA, Kaushik S, Pérez-Sánchez J, Sitjà-Bobadilla A.

 

2012. Effect of the nutritional background and the infection by the parasite Enteromyxum leei (Myxozoa: Myxosporea) on the mucosal carbohydrate pattern of the intestine of gilthead sea bream (Sparus aurata).  Dis Aquat Org 100: 29-42. Estensoro I, Redondo MJ, Sales B, Kaushik S, Pérez-Sánchez J, Sitjà-Bobadilla A.

 

2012. Molecular profiling of the gilthead sea bream (Sparus aurata) response to chronic exposure to the myxosporean parasite Enteromyxum leei. Molecular Immunol 48: 2102-12. Davey GC, Calduch-Giner JA, Houeix B, Talbot A, Sitjà-Bobadilla A, Prunet P, Pérez-Sánchez J, Cairns MT.

 

2013. Effect of ration size on fillet fatty acid composition, phospholipid allostasis and mRNA expression patterns of lipid regulatory genes in gilthead sea bream. British J Nutrition 109: 1175-87. Benedito-Palos L, Calduch-Giner JA, Ballester-Lozano G, Pérez-Sánchez J.

 

2013. Dietary oils mediates cortisol kinetics and the expression pattern of liver stress responsive genes in juveniles of gilthead sea bream exposed to crowding stress. Comp Biochem Physiol 8D: 123-30. Pérez-Sánchez J, Borrel M, Bermejo-Nogales A, Benedito-Palos L, Saera-Vila A, Calduch-Giner JA, Kaushik S.

 

2013. Deep sequencing for de novo construction of a marine fish (Sparus aurata) transcriptome database with a large coverage of protein-coding transcripts. BMC Genomics 14: 178. Calduch-Giner JA, Bermejo-Nogales A, Benedito-Palos L, Estensoro I, Ballester-Lozano G, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2013. Dietary oils mediate cortisol kinetics and the hepatic expression profile of stress responsive genes in juveniles of gilthead sea bream (Sparus aurata) exposed to crowding stress. Comp Biochem Physiol D8: 123-30. Pérez-Sánchez J, Borrel M, Bermejo-Nogales A, Benedito-Palos L, Saera-Vila A, Calduch-Giner JA, Ballester-Lozano GF.

 

2013. Mucins as diagnostic and prognostic biomarkers in a fish-parasite model: transcriptional and functional analysis. PLoS One 8: e65457. Pérez-Sánchez J, Estensoro I, Redondo MJ, Calduch-Giner JA, Kaushik S, Sitjà-Bobadilla A.

 

2014. Dummy regression analysis for modelling the nutritionally tailored fillet fatty acid composition of turbot and sole using gilthead sea bream as a reference subgroup category. Aquaculture Nutrition. 20(4): 421-430. Ballester-Lozano GF, Benedito-Palos L, Riaza A, Navarro JC, Rosel J, Pérez-Sánchez J.

 

2014. Tissue-specific gene expression and functional regulation of uncoupling protein 2 (UCP2) by hypoxia and nutrient availability in gilthead sea bream (Sparus aurata): Implications on the physiological significance of UCP1-3 variants. Fish Physiol Biochem 40(3): 751-62. Bermejo-Nogales A, Calduch-Giner JA, Pérez-Sánchez J.

 

2014. Acute stress response in gilthead sea bream (Sparus aurata L.) is time-of-day dependent: Physiological and oxidative stress indicators. Chronobiol Int 31: 1051-61. Vera LM, Montoya A, Pujante IM, Pérez-Sánchez J, Calduch-Giner JA, Mancera JM, Moliner J, Sánchez-Vázquez FJ.

 

2014. Metabolic and transcriptional responses of gilthead sea bream (Sparus aurata L.) to environmental stress: New insights in fish mitochondrial phenotyping. Gen Comp Endocrinol 205: 305-15. Bermejo-Nogales A, Nederlof M, Benedito-Palos L, Ballester-Lozano GF, Folkedal O, Olsen RE, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2014. Wide-gene expression analysis of lipid-relevant genes in nutritionally challenged gilthead sea bream (Sparus aurata). Gene 547: 34-42. Benedito-Palos L, Ballester-Lozano GF, Pérez-Sánchez J.

 

2014. Transcriptional assessment by microarray analysis and large-scale meta-analysis of the metabolic capacity of cardiac and skeletal muscle tissues to cope with reduced nutrient availability in gilthead sea bream (Sparus aurata L.). Marine Biotechnol 16: 423–35. Calduch-Giner JA, Echasseriau Y, Crespo D, Baron D, Planas JV, Prunet P, Pérez-Sánchez J.

 

2014. Interleukin gene expression is strongly modulated at the local level in a fish-parasite model. Fish Shellfish Immunol 37: 201-8. Pérez-Cordón G, Estensoro I, Benedito-Palos L, Calduch-Giner JA, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2014. Screening of pesticides and polycyclic aromatic hydrocarbons in feeds and fish tissues by gas chromatography coupled to high-resolution mass spectrometry using atmospheric pressure chemical ionization. J Agriculture Food Chem 62: 2165-74. Nácher-Mestre J, Serrano R, Portolés T, Berntssen MHG, Pérez-Sánchez J, Hernández F.

 

2014. Up-scaling validation of a dummy regression approach for predictive modelling the fillet fatty acid composition of cultured European sea bass (Dicentrarchus labrax). Aquaculture Res. 47: 1067-1074. Ballester-Lozano GF, Benedito-Palos L, Mingarro M, Navarro JC, Pérez-Sánchez J.

 

2014. A new intranuclear microsporidium, Enterospora nucleophila n. sp., causing emaciative syndrome in a piscine host (Sparus aurata L.), prompts the redescription of the family Enterocytozoonidae. International Journal for Parasitology 44:189-203. Palenzuela O, Redondo MJ, Cali A, Takovrian P, Alonso-Naveiro M, Alvarez-Pellitero P, Sitjà-Bobadilla A.

 

2014. RNA-seq analysis reveals significant transcriptome changes in turbot (Scophthalmus maximus) suffering severe enteromyxosis. BMC Genomics 15:1149. Robledo D, Ronza P, Losada AP, Bermúdez R, Pardo BG, Redondo MJ, Harrison PW, Sitjà-Bobadilla A, Quiroga MI, Martínez, P.

2015. European sea bass (Dicentrarchus labrax) immune status and disease resistance are impaired by arginine dietary supplementation. PLoS ONE 10:e0139967. Azeredo R, Pérez-Sánchez J, Sitjà-Bobadilla A, Fouz B, Tort L, Aragão C, Oliva-Teles A, Costas B.

 

2015. Growth-promoting effects of sustained swimming in fingerlings of gilthead sea bream (Sparus aurata L.). Journal of Comparative Physiology B 185: 859-868. Blasco J, Moya A, Millán-Cubillo A, Vélez EJ, Capilla E, Pérez-Sánchez J, Gutiérrez J, Fernández-Borràs J.

 

2015. Corallochytrium limacisporum and Ichthyosporea form an independent group of cell-walled osmotrophs within Opisthokonta. Current Biology 25: 2404-2410. Torruella G, De Mendoza A, Grau-Bové X, Donachie S, Pérez-Cordón G, Sitjà-Bobadilla A, Paley R, Manohar, CS, Nichols K, Eme l,  Del Campo J, Ruiz-Trillo I.

 

2015. Effect of temperature on the metabolism, behaviour and oxygen requirements of Sparus aurata. Aquaculture Environment Interactions 7: 115-123. Remen M, Nederlof MAJ, Folkedal O, Thorsheim G, Sitjà-Bobadilla A, Pérez-Sánchez J, Oppedal F, Olsen RE.

 

2015. Immunohistochemical detection and gene expression analysis of TNFα in turbot (Scophthalmus maximus) enteromyxosis. Fish & Shellfish Immunology 47: 368-376. Ronza P, Bermúdez R, Losada AP, Sitjà-Bobadilla A, Pardo BG, Quiroga MI.

 

2015. Effects of dietary NEXT ENHANCE®150 on growth performance and expression of immune and 2 intestinal integrity related genes in gilthead sea bream (Sparus aurata L.). Fish Shellfish Immunol 44(1): 117-28. Pérez-Sánchez J, Benedito-Palos L, Estensoro I, Petropoulos Y, Calduch-Giner JA, Browdy CL, Sitjà-Bobadilla A.

 

2015. Occurrence and potential transfer of mycotoxins in gilthead sea bream and Atlantic salmon by use of novel alternative feed ingredients. Chemosphere 128: 314-20. Nácher-Mestre J, Serrano R, Beltrán E, Pérez-Sánchez J, Silva J, Karalazos V, Hernández F, Berntssen MH.

 

2015. Cyprinid herpesvirus 3 Il10 inhibits inflammatory activities of carp macrophages and promotes proliferation of Igm+ B cells and memory T cells in a manner similar to carp Il10. Journal of Immunology 195: 3694-3704. Piazzon MC, Wentzel AS, Tijhaar EJ, Rakus K, Vanderplasschen A, Wiegertjes GF, Forlenza M.

 

2015. Unraveling the molecular signatures of oxidative phosphorylation to cope with the nutritionally changing metabolic capabilities of liver and muscle tissues in farmed fish.  PLoS ONE 10:e0122889. Bermejo-Nogales A, Calduch-Giner JA, Pérez-Sánchez J.

 

2015. Daily rhythms of clock gene expression and feeding behavior during the larval development in gilthead seabream, Sparus aurata. Chronobiol Int 32(8):1061-74. Mata-Sotres JA, Martínez-Rodríguez G, Pérez-Sánchez J, Sánchez-Vázquez FJ, Yúfera M.

 

2015. Comprehensive biometric, biochemical and histopathological assessment of nutrient deficiencies in gilthead sea bream fed semi-purified diets. British Journal of Nutrition 114: 713-726. Ballester-Lozano GF, Benedito-Palos l., Estensoro I, Sitjà-Bobadilla A, Kaushsik S, Pérez-Sánchez J.

 

2016. Long-term epidemiological survey of Kudoa thrysites (Myxozoa) in Atlantic salmon (Salmo salar) Canadian farms. J. Fish Dis. 39: 929-946. Marshall WL, Sitjà-Bobadilla A, Brown HM, MacWilliam T, Richmond Z, Lamson H, Morrison DB, Afonso LOB.

 

2016. Development of different diagnostic techniques for Endolimax piscium (archamoebae) and their applicability in Solea senegalensis clinical samples. Journal of Fish Diseases 39:1433-1443. Constenla M, Padrós F, Del Pozo R, Palenzuela O.

 

2016. IL10, a tale of an evolutionary conserved cytokine across vertebrates. Critical Reviews in Immunology 36: 99-129. Piazzon MC, Lutfalla G, Forlenza M.

 

2016. New cell motility model observed in parasitic cnidarian Sphaerospora molnari (Myxozoa:Myxosporea) blood stages in Fish. Sci. Rep. 6:39093. Hartigan A, Estensoro I, Vancová M, Bílý T, Patra S, Eszterbauer E, Holzer AS.

 

2016. Unraveling the Tissue-Specific Gene Signatures of Gilthead Sea Bream (Sparus aurata L.) after Hyper- and Hypo-Osmotic Challenges. PLoS ONE 11:e0148113. Martos-Sitcha JA, Mancera JM, Calduch-Giner JA, Yúfera M, Martínez-Rodríguez G, Pérez-Sánchez J.

 

2016. Cimetidine disrupts the renewal of testicular cells and the steroidogeneis in a hermaphroditic fish. Comparative Biochemistry and Physiology C 189: 44-53. García-García M, Liarte S, Gómez-González NE., García Alcazar A, Pérez-Sánchez J, Meseguer J, Mulero V, García Ayala A, Chaves-Pozo E.

 

2016. Long-term epidemiological survey of Kudoa thrysites (Myxozoa) in Atlantic salmon (Salmo salar) Canadian farms. Journal of Fish Diseases 39: 929-946. Marshall WL, Sitjà-Bobadilla A, Brown HM, MacWilliam T, Richmond Z, Lamson H, Morrison DB, Afonso LOV.

 

2016. RNA-seq analysis of early enteromyxosis in turbot (Scophthalmus maximus): new insights on host-parasite interaction. International Journal of Parasitology 46: 507–517. Ronza P, Robledo D, Bermúdez R, Losada AP, Pardo BG, Sitjà-Bobadilla A, Quiroga MI, Martínez P.

 

2016. Effects of sustained exercise on GH-IGFs axis in gilthead sea bream (Sparus aurata). American Journal of Physiology-Regulatory Integrative and Comparative Physiology 310: R313-R322. Velez EJ, Azizi S, Millan-Cubillo A, Fernández-Borras J, Blasco J, Calduch-Giner JA, Pérez-Sánchez J, Navarro I, Capilla E, Gutiérrez, J.

 

2016. Immunity to gastrointestinal parasites of fish. Development & Comparative Immunology 64: 187-201 (2016). Sitjà-Bobadilla A, Estensoro I, Pérez-Sánchez J.

 

2016. Wide-targeted gene expression infers tissue-specific molecular signatures of lipid metabolism in fed and fasted fish. Reviews in Fish Biology and Fisheries 26: 93-108. Rimoldi S, Benedito-Palos L, Terova G, Pérez-Sánchez J.

 

2016. Dietary butyrate helps to restore the intestinal status of a marine teleost (Sparus aurata) fed extreme diets low in fish meal and fish oil. PLoS ONE 11:e0166564. Estensoro I, Ballester-Lozano GF, Benedito-Palos L, Grammes F, Martos-Sitcha JA, Mydland L.-T, Calduch-Giner JA, Fuentes J, Karalazos V, Ortiz A, Øverland M, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2016. Gene expression profiling reveals functional specialization along the intestinal tract of a carnivorous teleostean fish (Dicentrarchus labrax). Frontiers in Physiology 7: 359. Calduch-Giner JA, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2016. Lasting effects of butyrate and low FM/FO diets on growth performance, blood haematology/biochemistry and molecular growth-related markers in gilthead sea bream (Sparus aurata). Aquaculture 454: 8-18. Benedito-Palos L, Ballester-Lozano GF, Simó P, Karalazos V, Ortiz A, Calduch-Giner JA, Pérez-Sánchez, J.

 

2016. Up-scaling validation of a dummy regression approach for predictive modelling the fillet fatty acid composition of cultured European sea bass (Dicentrarchus labrax). Aquaculture Research 47: 1067-1074. Ballester-Lozano GF, Benedito-Palos L, Mingarro M, Navarro JC, Pérez-Sánchez, J.

 

2016. Differential modulation of IgT and IgM upon parasitic, bacterial, viral and dietary challenges in a perciform fish. Frontiers in Immunology 7: 637. Piazzon C, Galindo_Villegas J, Pereiro P, Estensoro I, Calduch-Giner JA, Gómez-Casado E, Novoa B, Mulero V, Sitjà-Bobadilla A, Pérez-Sánchez, J.

 

2017. Skin mucus of gilthead sea bream (Sparus aurata L.). Protein mapping and regulation in chronically stressed fish. Frontiers in Physiology 8: 34. Pérez-Sánchez J, Terova G, Simó-Mirabet P, Rimoldi S, Folkedal O, Calduch-Giner JA, Olsen RE, Sitjà-Bobadilla A.

 

2017. Untargeted  metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata). PeerJ 5: e2920. Gil-Solsona R, Nacher-Mestre J, Lacalle-Bergeron L, Vicente Sancho J, Calduch-Giner JA, Hernández F, Pérez-Sánchez J.

 

2017. Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata). Journal of Comparative Physiology, 187:153-163. Simó-Mirabet P, Bermejo-Nogales A, Calduch-Giner JA, Pérez-Sánchez J.

 

2017. Comprehensive strategy for pesticide residue analysis through the production cycle of gilthead sea bream and Atlantic salmon. Chemosphere, 179: 242-253. Portoles T, Ibañez M, Garlito B, Nácher-Mestre J, Karalazos V, Silva J, Alm M, Serrano R, Pérez-Sánchez J, Hernández F, Berntssen MHG.

 

2017. Multi-class determination of undesirables in aquaculture samples by gas chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization: A novel approach for polycyclic aromatic hydrocarbons. Talanta, 172: 109-119. Portoles T, Garlito B, Nácher-Mestre J, Berntssen MHG, Pérez-Sánchez J.

 

2017. Olive-oil bioactive compounds improve growth, gut health and integrity in gilthead sea bream (Sparus aurata). British Journal of Nutrition 117: 351-363. Gisbert E, Andree KB, Quintela JC, Calduch-Giner JA, Ipharraguerre IR, Pérez-Sánchez J.

 

2017. Dietary Supplementation of heat-treated Gracillaria and Ulva seaweeds enhanced acute hypoxia tolerance in gilthead seabream (Sparus aurata). Biology Open doi:10.1242/bio.024299. Magnoni LJ, Martos-Sitcha JA, Queiroz A, Calduch-giner JA, Magalhàes Gonçalves JF, Rocha CMR, Abreu HT, Schrama JW, Ozorio ROA, Pérez-Sánchez J.

Books & Books Chapters

2015. Sitjà-Bobadilla A, Schmidt-Posthaus H, Wahli T, Holland JW, Secombes, C.J. Fish Immune responses to Myxozoan infections. pp: 253-280. En: “Myxozoan Evolution, Ecology and Development”. Editores: B. Okamura, A., Gruhl & J. Bartholomew. Springer International Publishing Switzerland. ISBN 978-3-319-14752-9, 441 pp.

 

2017. Sitjà-Bobadilla A, Oidtmann B. Integrated pathogen management strategies. Capítulo 5: 119-144. En: “Fish Diseases: Prevention and Control Strategies”. Ed. Galina Jeney. Academic Press. ISBN: 9780128045640, 278 pp.

Conference communications (participation)

2008. Differential tissue expression of uncoupling proteins in gilthead sea bream (Sparus aurata): Lessons from UCP1 and UCP3 in fish. 25th Congress of the European Society of Comparative Biochemistry and Physiology. September. Ravenna, Italy. Bermejo Nogales A, Saera-Vila A, Benedito-Palos L, Calduch-Giner J, Pérez-Sánchez J

 

2008. Time series analyses of sea bream stress response alter confinement exposure. 25th Congress of the European Society of Comparative Biochemistry and Physiology. September. Ravenna, Italia. Calduch-Giner J, Saera-Vila A, Cairns M, Davey G, Pérez-Sánchez J.

 

2009. Gilthead sea bream microarray analysis of alterations induced by essential fatty acid deficiencies in the adipose tissue gene expression profiling. 7º Congreso de la Sociedad Europea de Endocrinología Comparada. 6-9 Septiembre. Oporto (Portugal). Calduch-Giner JA, Saera-Vila A,  Pérez-Sánchez J.

 

2010. Improvement of aquaculture production by the use of biotechnological tools (AQUAGENOMICS). Aquaculture Europe 2010. Porto (Portugal), 5-8 Octubre. Novoa B, Martínez P, Piferrer F, Mackenzie S, Planas JV, Morán F, Toranzo AE, Mulero V, Sanchez FJ, Estepa A, Coll J, Tort L, Yufera M, Pérez J, Zanuy S, Cerdá JM, Toro MA, Rejón MR, Figueras A.

 

2010. In vivo lipolytic effects of PPAR-beta in the adipose tissue of gilthead sea bream. 9th International Congress on the Biology of Fish. 5-9 July. Barcelona. Saera-Vila A, Pérez-Sánchez J.

 

2010. Tissue-specific regulation of energy wastage and uncoupling protein 3 (UCP3) in muscle tissues of gilthead sea bream. 9th International Congress on the Biology of Fish. 5-9 July. Barcelona. Bermejo-Nogales A, Benedito-Palos L, Calduch-Giner JA, Pérez-Sánchez J.

 

2010. Use of oligo-microarray technology for the assessment of nutritional stress in the adipose tissue of gilthead sea bream fed vegetable oils. A nutritional-induced model of lipodystrophy. 9th International Congress on the Biology of Fish. 5-9 July. Barcelona. Calduch-Giner JA, Saera-Vila A, Pérez-Sánchez J.

 

2011. Efectos de la ración sobre los perfiles de ácidos grasos en músculo de dorada (Sparus aurata). Control alostático de los fosfolípidos. XIII Congreso Nacional de Acuicultura. 21-24 November. Castelldefels. Benedito-Palos L, Calduch-Giner JA, Pérez-Sánchez J.

2011. Análisis transcripcional de la respuesta al estrés por confinamiento en doradas (Sparus aurata L.) alimentadas con aceites vegetales. XIII Congreso Nacional de Acuicultura. 21-24 November. Castelldefels. Borrel-Roda M, Benedito-Palos L, Calduch-Giner JA, Pérez-Sánchez J.

2011. Modelos de regresión multi-lineal para la predicción del perfil de ácidos grasos de filetes de dorada en cultivo. XIII Congreso Nacional de Acuicultura. 21-24 November. Castelldefels. Ballester-Lozano GF, Benedito-Palos L, Navarro JC, Kaushik S, Pérez-Sánchez J.

2011. Are peroxiredoxin genes predictive biomarkers of health and welfare in aquacultured fish? Answers for gilthead sea bream. BIT's 1st Annual World Congress of Microbes-2011(WCM-2011), 1st Annual Symposium of Antiparasites (SAP). July 30- August 1. Beijing (China). Pérez-Sánchez J, Bermejo-Nogales A, Calduch-Giner J, Kaushik S, Sitjà-Bobadilla A.

2011. Effects of the nutritional background and parasite infection on the intestine transcriptome of gilthead sea bream, Sparus aurata. 8º Congreso de la Asociación Ibérica de Endocrinología Comparada. 5-7 Septiembre. Madrid. Calduch-Giner JA, Sitjà-Bobadilla A, Pérez-Sánchez J

2011. Development and validation of rabbit polyclonal antibodies raised against uncoupling proteins of gilthead sea bream, Sparus aurata. 8º Congreso de la Asociación Ibérica de Endocrinología Comparada. 5-7 September. Madrid. Bermejo-Nogales A, Borrel-Roda M, Pérez-Sánchez J.

2011. Modulation of the gene expression of IgM and distribution of IgM+ cells by nutritional background and infection by Enteromyxum leei (Myxozoa) in gilthead sea bream (Sparus aurata). 15th International EAFP Conference on Diseases of Fish and Shellfish. 12-16 September. Split (Croatia). Estensoro I, Calduch-Giner JA, Kaushik S, Pérez-Sánchez J, Sitjà-Bobadilla A.

 

2012. Investigación, desarrollo tecnológico e innovación en acuicultura marina.  Proyecto MEDITERRANE-ON “Definición de indicadores de sostenibilidad en la acuicultura Mediterránea” Ministerio de Agricultura Pesca y Alimentación, Madrid, September 2012. Pérez-Sánchez J.

 

2012. Mucins as prognostic and diagnostic molecular markers of intestinal health in gilthead sea bream (Sparus aurata): Implications of the nutritional background. XV International Symposium on Fish Nutrition. Molde, Noruega, Junio. Pérez-Sánchez J, Calduch-Giner JA, Estensoro I, Redondo MªJ, Kaushik S, Sitjà-Bobadilla A

 

2012. Building on the transcriptome of gilthead sea bream (Sparus aurata). De novo assembly of next-generation sequencing data. XV International Symposium on Fish Nutrition. Molde, Norway, June. Calduch-Giner JA, Borrel M, Pérez-Sánchez J.

 

2013. Can a parasitic infection modulate the expression of interleukin genes in a fish-myxozoan system? First International Conference on Fish & Shellfish Immunology. 25-28 June. Vigo. Pérez-Cordón G, Estensoro I, Benedito-Palos L, Calduch-Giner JA, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2013. Effect of Next Enhance® 150 and Previda® on growth performance and the intestinal transcriptome of gilthead sea bream (Sparus aurata). Aquaculture conference: To the Next 40 Years of Sustainable Global Aquaculture. 3-7 November. Las Palmas de Gran Canaria. Pérez-Sánchez J, Bermejo-Nogales A, Benedito-Palos L, Estensoro I, Petropoulos Y, Palenzuela O, Browdy CL, Sitjà-Bobadilla A.

 

2013. Effects of butyrate feed supplementation on gilthead sea bream (Sparus aurata) growth performance and intestinal health: A transcriptomic approach. Aquaculture conference: To the Next 40 Years of Sustainable Global Aquaculture. 3-7 November. Las Palmas de Gran Canaria. Pérez-Sánchez J, Bermejo-Nogales A, Grammes F, Pérez-Cordón G, Øverland M, Calduch-Giner JA, Mallo JJ, Sitjà-Bobadilla A, Ballester-Lozano G.

 

2013. Mitochondria as key responders of metabolic and hormonal disturbances in fish. Meta-analysis flowchart of transcriptomic data in gilthead sea bream (Sparus aurata). 17th International Congress of Comparative Endocrinology. 15-19 July. Barcelona. Calduch Giner J, Echasseriau Y, Prunet P, Pérez-Sánchez.

 

2013. Transcriptional-metabolic phenotyping of gilthead sea bream (Sparus aurata) mitochondria. 17th International Congress of Comparative Endocrinology. 15-19 July. Barcelona. Bermejo-Nogales A, Nederlof M, Olsen RE, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2014. Advanced analytical approaches to investigate the presence of undesirables from feed to fish. Atlantic salmon and gilthead sea bream as a case study. Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Nácher J, Serrano R, Boix B, Bade B, Karalazos P,  Berntssen S, Pérez Sánchez J, Hernández F.

 

2014. Applicability of sustained swimming for gilthead sea bream (Sparus aurata) fingerlings farming. Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Millán-Cubillo A, Fernández-Borràs J, Vélez EJ, Moya A, Azizi S, Capilla E, Ibarz A, Pérez-Sánchez J, Gutiérrez J, Blasco J.

 

2014. Histopathological and transcriptional scoring of intestinal traits in gilthead sea bream (Sparus aurata) fed low fish meal and fish oil diets with butyrate supplementation. Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Estensoro I, Ballester G, Benedito L, Mallo K, Sitjà Bobadilla A, Kaushik S, Pérez-Sánchez J.

 

2014. Innovative biomarkers for environmental and nutritional stressors in sea bream. Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 Octubre. Sitjà Bobadilla A, Pérez Sánchez J.

 

2014. Molecular characterization and functional regulation of mitochondrial respiratory chain in gilthead sea bream (Sparus aurata). Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Calduch J, Bermejo A, Pérez-Sánchez J.

 

2014. Mycotoxins, are they really a problem in aquaculture? Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Serrano R, Nácher J, Berntssen B, Karalazos S, Pérez Sánchez J, Hernández F.

 

2014. Nutritionally-mediated changes of butyrate feed supplementation in the composition of gut microbiota, immune response and protection against photobacteriosis in gilthead sea bream (Sparus aurata).  Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Fouz B, Cuevas M, Diéguez C, Estensoro I, Pérez Sánchez J, Sitjà Bobadilla A.

 

2014. The changing gene expression profile induced by fasting and refeeding in European sea bass (Dicentrarchus labrax). Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Rimoldi S, Benedito L, Terova G, Pérez Sánchez J

 

2014. The gene expression gradient through the intestine tract of European sea bass (Dicentrarchus labrax). Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Calduch J, Pérez Sánchez J

 

2014. Towards a multi-species prediction model of fillet fatty acid composition in marine farmed fish. Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October. Ballester GF, Benedito L, Mingarro M, Navarro JC, Pérez Sánchez J.

 

2014. Wide-gene expression analysis of lipid-relevant genes in nutritionally challenged gilthead sea bream (Sparus aurata). Aquaculture Europe 14. San Sebastián, País Vasco, Spain.14-17 October.

 

2014. Effects of long-term feeding at maintenance ration on the onset of pUBerty of male sea bass (Dicentrarchus labrax L.): Special emphasis on seasonal plasma levels of IGF-I and leptin. 27th Conference of European Comparative Endocrinologists Rennes, Bretagne, France 25-29 August. Escobar S, Felip A, Ballester G, Johansson M, Pérez-Sánchez J, Thrandur B, Zanuy S, Carrillo M.

 

2015. Immunomodulatory effect of dietary arginine on the European seabass (Dicentrarchus labrax) immune response. IV Encontro Nacional de Pós-graduação em Ciências Biológicas. Aveiro, Portugal, 30 Marzo-2 Abril. Azeredo R, Tort L, Oliva-Teles A, Pérez-Sánchez J, Sitjà-Bobadilla A, Costas B.

 

2015. Comprehensive analysis of the regulatory activities of carp Il10 on Igm+ B lymphocytes and on T lymphocytes.  13th International Society of Developmental and Comparative Immunology Congress. Murcia, España, 28 Junio-2 Julio. Piazzon MC, Savelkoul HFJ, Pietretti D, Wiegertjes GF, Forlenza M.

 

2015. Bromodeoxyuridine DNA labelling reveales the host intestinal proliferation induced by a myxozoan parasite and the time-space dependent proliferation of the parasitic stages.  9th International Symposium on Fish Parasites. Valencia, España, 31 Agosto-4 Septiembre.  Pérez-Cordón, G, Estensoro I, Sitjà-Bobadilla A.

 

2015. Differential humoral immune response of gilthead sea bream (Sparus aurata) resistant to Enteromyxum leei (Myxozoa) re-infection. 17th International Conference on Diseases of Fish and Shellfish. Las Palmas, España, 7-11 Septiembre. Estensoro I, Del Pozo R, Sitjà-Bobadilla A.

 

2015. Effect of nutritional interventions on immune response and gut health of gilthead sea bream (Sparus aurata).                17th International Conference on Diseases of Fish and Shellfish. Las Palmas,       España, 7-11 Septiembre. Sitjà-Bobadilla, A, Estensoro I,  Calduch-Giner J,  Fouz B, Browdy CL, Ortiz A, Pérez-Sánchez J.

 

2015. Monitoring parasite incidence in gilthead sea bream held in experimental and production cages: long-term effect of a supplemented diet on fish health. 17th International Conference on Diseases of Fish and Shellfish. Las Palmas, España, 7-11 Septiembre. Palenzuela O, Browdy CL, Petropoulos Y, Katribouzas N, Del Pozo R, Sitjà-Bobadilla A.

 

2015. Outbreak of cryptosporidiosis in sea caged turbot (Psetta maxima). 17th International Conference on Diseases of Fish and Shellfish. Las Palmas, España, 7-11 Septiembre. Fioravanti ML, Quaglio F, caffara M, Gustinelli A, Palenzuela O, Krizanac S, Čolak S.

 

2015. Hyper- and hypo-osmotic challenges modify hormonal pathways in the gilthead sea bream (Sparus aurata): a microarray approach. 10º Congreso de la Asociación Ibérica de Endocrinología Comparada. Castellón, España, 23-25 Septiembre. Martos-Sitcha JA, Mancera JM, Calduch-Giner JA, Pérez-Sánchez J, Yúfera M, Martínez-Rodríguez G.

 

2015. Energy sensing in gilthead sea bream. Molecular and functional characterization of sirtuins. 10º Congreso de la Asociación Ibérica de Endocrinología Comparada.            Castellón, España, 23-25 Septiembre. Simó P, Calduch-Giner JA, Pérez-Sánchez J.

 

2015. Wide-transcriptomic analysis of intestine in Mediterranean Fish. 10º Congreso de la Asociación Ibérica de Endocrinología Comparada. Castellón, España, 23-25 Septiembre. Pérez-Sánchez J, Calduch-Giner JA, Sitjà-Bobadilla A.

 

2015. Multi-class screening of feedstuff contaminants and potential endocrine disruptors in farmed Fish. 10º Congreso de la Asociación Ibérica de Endocrinología Comparada. Castellón, España, 23-25 Septiembre. Nácher-Mestre J, Serrano R, Ibáñez M, Portolés T, Berntssen MHG, Hernández F, Pérez-Sánchez J.

 

2015. Serum metabolome of fasted gilthead sea bream. A non-targeted approach for the identification of robust biomarkers of malnutrition in fish. 10º Congreso de la Asociación Ibérica de Endocrinología Comparada. Castellón, España, 23-25 Septiembre. Gil Solsona R, Nácher-Mestre J, Lacalle L, Calduch-Giner JA, Sancho JV, Hernández F, Pérez-Sánchez J.

 

2015. Non-targeted UHPLC-HRMS based metabolomics for the identification of nutritional variations in fish serum. XV Reunión Científica de la Sociedad Española de Cromatografía y Técnicas Afines (SECyTA2015)/VII Reunión Nacional de la Sociedad Española de Espectrometría de Masas (SEEM2015). Castellón, España, 27-30 Octubre. Lacalle L, Gil R, Nácher J, Calduch-Giner J, Sancho JV, Hernández F, Pérez-Sánchez J.

 

2015. Multi-class determination of polycyclic aromatic hydrocarbons, pesticides and polychlorinated biphenyls in aquaculture samples by gas chromatography/ tandem mass spectrometry with atmospheric pressure chemical ionization. XV Reunión Científica de la Sociedad Española de Cromatografía y Técnicas Afines (SECyTA2015)/VII Reunión Nacional de la Sociedad Española de Espectrometría de Masas (SEEM2015)         . Castellón, España, 27-30 Octubre. Garlito, B, Portolés P, Nácher-Mestre J, Berntssen MHG, Serrano R, Pérez-Sánchez J, Hernández F.

 

2016. Cambios en la expresión proteica y génica de la E-cadherina intestinal de dos peces teleósteos inducidos por Enteromyxum spp. (Myxozoa). XXVII Reunión de la Sociedad Española de Anatomía Patológica Veterinaria. Córdoba, España, 8-10 junio. Ronza P, Estensoro I, Bermúdez R, Losada AP, Pérez-Cordón G, Pardo BG, Pérez-Sánchez J, Sitjà-Bobadilla A, Quiroga MI.

 

2016. Functional plasticity of the intestine of Mediterranean farmed fish to cope with environmental and nutritional stressors             . 8th International Symposium on Fish Endocrinology, Gotemburgo, Suecia. 28 Junio-2 Julio.                Calduch-Giner J, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2016. Key performance indicators from early life stages to completion of sexual maturation in three year-old gilthead sea bream (Sparus aurata). Aquaculture Europe 2016, Edimbugo, Escocia. 20-23 Septiembre. Simó-Mirabet P., Calduch-Giner JA, Ballester-Lozano GF, Benedito-Palos L, Felip A, Karalazos V, Ortiz A, Kaushik S, Pérez-Sánchez J.

 

2016. New tools and strategies for the metabolic phenotyping at molecular level of Mediterranean farmed fish. Aquaculture Europe 2016, Edimbugo, Escocia. 20-23 Septiembre. Calduch-Giner J, Benedito-Palos L, Estensoro I, Martos-Sitcha JA, Martínez-Rodríguez G, Yúfera M, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2016. Diet effects on the gut microbiota and intestinal mucus proteome are linked to changes in the disease outcome due to the intestinal parasite Enteromyxum leei in gilthead sea bream (Sparus aurata).  Aquaculture Europe 2016, Edimbugo, Escocia. 20-23 Septiembre. Piazzon C, Calduch-Giner JA, Simó-Mirabet P, Estensoro I, Ortiz A, Karalazos V, Palenzuela O, Fouz B, Sitjà-Bobadilla A, Pérez-Sánchez J.

 

2016. Parafishcontrol, a European Union funded project gathering academia and companies to combat parasitic diseases in farmed fish.  International Fisheries Symposium – IFS 2016. Phu Quoc Island, Vietnam, 31 Octubre-2 Noviembre. Székely C, Reuver M, Junge C, Sitjà-Bobadilla A.

Conference communications (invitation)

2009. Fish farming. Food safety and sustainable development. Ciencia y Sociedad. Conference cycle.

 

2009. Aquaculture flashforward. The use of novel fish feeds in a scenario of global change. Ciencia y Sociedad. Conference cycle.

Thesis

2011. Jaime Nácher Mestre. University Jaume I. Potencial del acoplamiento GC-MS para la determinación de contaminantes orgánicos en muestras de matriz compleja. Supervisors Serrano R, Pérez Sánchez J.

2012. Azucena Bermejo Nogales. University Politécnica de Valencia, Universitat Jaume I. Febrero 2012. Marcadores mitocondriales de estrés oxidativo y lipotoxicidad en dorada (Sparus aurata). Supervisor Pérez-Sánchez J.

2013. Gabriel Ballester Lozano. University Jaume I. Alimentos funcionales. Modelización matemática de los perfiles de ácidos grasos de peces en cultivo. Supervisor Pérez-Sánchez J.

 

2013. Maria Constenla Matalobos.  Universitat Autònoma de Barcelona. Contributions to the knowledge of a new disease caused by an amoeba in ongrowing Senegalese sole, Solea senegalensis (Kaup 1858).

2013. Itizar Estensoro Atienza. Universidad de Valencia. Enteromyxum leei (Myxozoa: Myxosporea) Infection in Gilthead Sea Bream (Sparus aurata): Immune-Related Studies.

2013. Juan Antonio Rielo Zurita. Universidad de Valencia. Desarrollo de un modelo matemático para la evaluación del proceso de crecimiento y engorde en los cultivos comerciales de dorada (Sparus aurata).

Master Degree

2012. Carla Olate Gallegos. “Master Interuniversitario de Acuicultura, UB-UAB-UPC”. Perspectivas del uso de macroalgas en piscicultura. Supervisor Pérez-Sánchez J.

Workshops

2014. Aquaculture research at the Spanish National Research Council, CSIC Who we are and what do we do? The numbers of CSIC.  (Seminarios de la Universidad de Ciencias Agrarias de Wuhan y el Instituto de Wuhan de la Academia de Ciencias China) Wuhan, China. 01-08 diciembre. Pérez-Sánchez J.

 

2014. Functional genomics in aquaculture. New insights in fish health and welfare.  (Seminarios de la Universidad de Ciencias Agrarias de Wuhan y el Instituto de Wuhan de la Academia de Ciencias China) Wuhan, China. 01-08 diciembre. Pérez-Sánchez J.

 

2014. Limits and constraints for alternative fish feeds in marine farmed fish. (Seminarios de la Universidad de Ciencias Agrarias de Wuhan y el Instituto de Wuhan de la Academia de Ciencias China) Wuhan, China. 01-08 diciembre. Pérez-Sánchez J.

 

2015. Impact of Myxozoa on Aquaculture: current and future control strategies (Workshop “Pathology of Aquatic Organisms”). Oporto, Portugal. Sitjà-Bobadilla A.

 

2015. Importancia de los parásitos en acuicultura: objetivos y actividades del Proyecto europeo “PARAFISHCONTROL” (VII Jornadas científico-técnicas sobre acuicultura sostenible. Sanidad animal en acuicultura: presente y futuro Grupo Marjal, Universidad de Alicante). Alicante, España. Sitjà-Bobadilla A.

 

2015. Parásitos en Acuicultura Marina Mediterránea (Seminarios del Instituto de Biología Molecular y Celular, Universidad Miguel Hernández (IBMC-UMH)). Elche, España. Palenzuela O.

 

2015. Functional plasticity of intestine. Present and future of key performance indicators in aquaculture? (Clausura del Master Interuniversitari d'Aqüicultura (Universitat de Barcelona, Universitat Politecnica de Cataluña, Universitat Autònoma de Barcelona)). Barcelona, España. Pérez-Sánchez J.

 

2015. Parasitic diseases in Mediterranean Aquaculture (Workshop “Epidemiology, prophylaxis and control of parasites in aquaculture”). Valencia, España. Palenzuela O.

 

2016. Avances y retos en el diagnóstico y control de las parasitosis en la piscicultura marina mediterránea (Jornada “Los problemas sanitarios de la piscicultura en el Levante español” organizada por REVIDPAQUA). Valencia, España. Sitjà-Bobadilla, A.

 

2016. El impacto de los Mixozoos en la acuicultura: Estrategias actuales y futuras para su control (I Ciclo de seminarios Instituto de Acuicultura Torre de la Sal). Castellón, España. Sitjà-Bobadilla, A.

 

2016. Interleuquina 10 en peces: Estudio de una citoquina regulatoria. (I Ciclo de seminarios Instituto de Acuicultura Torre de la Sal). Castellón, España. Piazzon, M.C.

 

2016. Anti-inflammatory cytokines: IL10 ((Zebra) Fish Immunology Workshop). Wageningen, Holanda. Piazzon, M.C.

 

2016. “Transnational access" en el IATS, CSIC y EUROPA a través de AQUAEXCEL: pasado y futuro (II Ciclo de seminarios Instituto de Acuicultura Torre de la Sal). Castellón, España. Sitjà-Bobadilla, A. & Calduch-Giner, J.

 

2016. Pescado de Crianza: los parásitos que NO comemos (Actividades del Día de la Acuicultura, en colaboración con el CEFIRE Castellón (Servicio de Formación al Profesorado) y el Ayuntamiento de Castellón de la Plana). Castellón, España. Sitjà-Bobadilla A.

 

2016. Disección y anatomía de un pez (Jornadas “Aprendiendo Ciencia en el CSIC” organizadas por el CEFIRE Castellón). Castellón, España. Sitjà-Bobadilla A. & Felip A.

Participation in another related projects

EU infrastructure research Project - Framework Programme 7. Aquaculture infrastructures for Excellence in European Fish Research (2011-2015). AQUAEXCEL.

 

INFRAIA-1-2014-2015, proposal 652831. Aquaculture infrastructures for Excellence in European fish research towards 2020 (pendiente del acuerdo de consorcio). AQUAEXCEL 2020.

 

EU-FP7-KBBE-2011-5 contract 288925. Advanced Research Initiatives for Nutrition and Aquaculture (2012-2016). ARRAINA.

 

H2020-IFP, grant agreement 634429. Advanced tools and Research Strategies for Parasite Control in European farmed fish (2015-2020). PARAFISHCONTROL.

 

FOOD-CT-2006-16249. Sustainable aquafeeds to maximise the health benefits of farmed fish for consumers (2006-2010). AQUAMAX.

 

(A service to assess impact of feed formulation on salmon nutritional condition, performance and waste output). UE ARRAINA 7PM (Diciembre 2015-Noviembre 2016). ASSESSFEED

 

H2020-SFS-2016-2, grant agreement 727610. PERFORMFISH. Consumer driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain (2017-2022).

Industry collaboration

Contract with NOVUS for the evaluation of the effects of the food additive Next Enhance NE150 on the parasites infections in sea bream

Contract with NOREL for the evaluation of the effects of the butirate suplementations on the intestinal health in sea bream under diverse immunological and nutritional changes.

Contrato con SKRETTING para evaluar el efecto de diferentes formulaciones de los piensos de dorada en el desarrollo de infecciones con el parásito intestinal Enteromyxum leei.

Contrato con NUTRIAD INTERNATIONAL NV para evaluar el efecto protector del aditivo  Sanacore en infecciones por mixozoos en la dorada.

 

Contrato con NOREL en dos fases para evaluar los efectos de dos aditivos, el prebiótico DICOSAN y el probiótico ECOBIOL, sobre el crecimiento y salud de doradas en cultivo.

 

Contrato con NOREL y BIOMAR para validar una segunda generación de aditivos para la mejora de caracteres productivos de interés en acuicultura como el crecimiento, el riesgo de estrés oxidativo y la salud intestinal.

 

Contrato con DMC RESEARCH CENTER S.L. para la evaluación de tratamientos terapéuticos y preventivos de Sparicotyle chrysophrii en dorada.

 

Stays in another labs

Itziar Estensoro visitó el grupo de INIA-1 del 16/10/2016 al 17/11/2016