The UAB-2 group has studied stress and welfare in aquaculture fish, as well as neuroendocrine interactions and activation of the innate immune response. In addition, aspects related to the effects of diet and immunostimulants both at the systemic and local levels (mucosal tissue) have been studied using transcriptomic tools (usually custom microarrays). Because stress states involve complex interactions and a close relationship with surrounding microorganisms and disease incidence, the UAB-2 team has focused its studies on immunoendocrine interactions, generating collaborations with groups working in reproductive physiology or growth, immunology, pathology and stress response, which allowed us to address challenges related to the management of fish in captivity. The collaborations carried out have allowed to carry out a better prediction and prevention of the diseases and to establish more precise conditions on wellfare in fish. The project Aquagenomics allowed the installation of a genomic platform of sea bream and sea bass that manages this group of the UAB. Thanks to this development, the UAB-2 team has established itself as a reference group in the area of transcriptomics, which has opened up the possibility of collaborating with the consortium groups Aquagenomics but also with external laboratories both in Spain and in the foreign. Among them University of Gent (Belgium), University of Santiago de Chile (Chile); University of Aveiro (Portugal); University of Mayor (Chile); University of Namur (Belgium); University of Valencia; University of Cádiz; IRTA Sabt Carles de la Rapita; Universidad de santaigo de Compostela.
2011. Stress and immune modulation in fish. Dev Comp Immunol 35: 1366-75. Tort L.
2011. Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory outcome in trout, Oncorhynchus mykiss, Macrophages. Sebastian Boltaña, Felipe Reyes-Lopez, Davinia Morera, Frederick Goetz, Simon A MacKenzie. BMC Genomics 12:34.
2012. Effects of chronic cortisol administration on global expression of GR and the liver transcriptome in Sparus aurata. Mar Biotechnol 15: 104–14. Teles M, Boltaña S, Reyes-López F, Santos MA, Mackenzie S, Tort L.
2013. Effects of chronic cortisol administration on global expression of GR and the liver transcriptome in Sparus aurata. Mariana Teles; Sebastian Boltaña; Felipe Reyes-López; Maria Ana Santos; Simon Mackenzie; Lluis Tort. Marine Biotechnology 15(1): 104-114.
2013. Differential expression of the corticosteroid receptors GR1, GR2 and MR in rainbow trout organs with slow release cortisol implants. Comp Biochem Physiol A 164: 506-11. Teles M, Tridico R, Callol A, Fierro-Castro C, Tort L.
2013. Effects of cortisol administered through slow-release implants on innate immune responses in rainbow trout (Oncorhynchus mykiss). Int J Genomics 2013: 619714. Cortés R, Teles M, Trídico R, Acerete L, Tort L.
2013. The LPS derived from the cell walls of the gram-negative bacteria Pantoea agglomerans stimulates growth and immune status of rainbow trout (Oncorhynchus mykiss) juveniles. Aquaculture 416-417: 272-79. Skalli A, Castillo M, Andree KB, Tort L, Furones D, Gisbert E.
2014. Lipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead sea bream). Fish Shellfish Immunol 39(2): 475-82. Boltaña S, Tridico RM, Teles M, Mackenzie S, Tort L.
2014. Hierarchical failure time regression using mixtures for classification of the immune response of Atlantic salmon. Jose S. Romeo, Renate Meyer, Felipe E. Reyes-Lopez. Journal of Agricultural, Biological, and Environmental Statistics, 19(4):501-521.
2015. Zebrafish liver (ZFL) cells are able to mount an anti-viral response after stimulation with Poly (I:C). Comp Biochem Physiol 182: 55-63. Ruyra A, Torrealba D, Morera D, Tort L, MacKenzie S, Roher N.
2015. Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV). Develop. & Comp. Immunol. 53:210-221. Reyes-López FE, Romeo JS, Vallejos-Vidal E, Reyes-Cerpa S, Sandino AM, Vidal R, Tort L, Mackenzie S, Imarai M.
2015. Mucosal immunity and B cells in teleosts: Effect of vaccination and stress. Felipe E. Reyes López, David Parra, Lluis Tort. Frontiers in Immunol. 6:354.
2015. An enriched European eel transcriptome sheds light upon host-pathogen interactions with Vibrio vulnificus. Agnès Callol, Felipe E. Reyes-López, Francisco J. Roig, Giles Goetz, Frederick W. Goetz, Carmen Amaro, Simon A. MacKenzie. PLOS ONE 10 (7), e0133328.
2015. Analysis of steroidogenic pathway key transcripts in interrenal cells isolated by laser microdissection (LMD) in stressed rainbow trout. Fierro-Castro, C., Santa-Cruz, M.C., Hernández-Sánchez, M., Teles, M. and Tort, L. Comp Biochem. Physiol. 190: 39-46.
2016. M. Teles, C. Fierro-Castro, P. Na-Phatthalung, A. Tvarijonaviciute, T. Trindade, A.M.V.M. Soares, L. Tort, M. Oliveira (2016). Assessment of gold nanoparticle effects in a marine teleost (Sparus aurata) using molecular and biochemical biomarkers. Aquatic Toxicology 177: 125–135.
2016. The response of fish to immunostimulant diets. Eva Vallejos-Vidal, Felipe Reyes-López, Mariana Teles, Simon Mackenzie. Fish & Shellfish Immunol. 56:34-69.
2017. Cellular and transcriptomic response to treatment with the probiotic candidate Vibrio lentus in gnotobiotic sea bass (Dicentrarchus labrax) larvae. Schaeck, M., Reyes-López, F.E., Vallejos-Vidal, E., Van Cleemput, J., Duchateau, L., Van den Broeck, Wim., Tort, L. and Decostere A. Fish Shellfish Immunol. 63 147-156
2017. Evaluation of gemfibrozil effects on a marine fish (Sparus aurata) combining gene expression with conventional endocrine and biochemical endpoints. Teles,M., C. Fierro-Castro,C., Na-Phatthalung, P. Tvarijonaviciute A., Soares, A.M. Tort L. and M. Oliveira. Journal of Hazardous Materials. 318: 600-607.
2017. Extending immunological profiling in the Gilthead Sea bream, Sparus aurata, by enriched cDNA library analysis, microarray design and initial studies upon the inflammatory response to PAMP. Boltaña S., Castellana B., Goetz G., Tort L., Teles M., Mulero V., Novoa B., Figueras A., Goetz F., Gallardo-Escarate C., Planas J., Mackenzie S. Int. J. Mol. Sci. 18:317-338.
2017. Linking cortisol response with gene expression in fish exposed to gold nanoparticles. Teles,M., A.M.V.M. Soares, A.M.V.M., Guimarães,L. Tort, L. and M. Oliveira M. Science of the Total Environment 584–585 (2017) 1004–1011
2017. Dietary β-glucans differentially modulate immune and stress-related gene expression in lymphoid organs from healthy and Aeromonas hydrophila-infected rainbow trout (Oncorhynchus mykiss). Douxfils, J., Fierro-Castro, C., Mandiki S.N.M., Emile W., Tort L., Kestemont P. Fish Shellfish Immunol. 63: 285-296.
2017. Cytokine modulation by stress hormones and antagonist specific hormonal inhibition in rainbow trout (Oncorhynchus mykiss) and gilthead sea bream (Sparus aurata) head kidney primary cell culture. Ali Reza Khansari, David Parra, Felipe Reyes-López, Lluis Tort. General and Comparative Endocrinology (Accepted).
2012. Genomic Responses to Stress Challenges in Fish. In: Functional Genomics in Aquaculture. Ed. By: M. Saroglia and Z. Liu. Wiley-Blackwell. 2012. Pp:147-168. Tort L, Teles M.
2012. Stress responses in rainbow trout. In: Trout. From physiology to conservation. Ed by: S. Polakoff and T.W. Moon. Nova PUB. New York, 2012. pp: 93-112. Tort L.
2012. Fish cytokines and immune response. Sebastián Reyes-Cerpa, Kevin Maisey, Felipe E. Reyes-López, Daniela Toro-Ascuy, Ana María Sandino, Mónica Imarai. In: “New Advances and Contributions to Fish Biology”. Intech.
2014. Tort, L., Rotllant, J., Pavlidis, M., Montero, D., & Terova, G. (2014). The Response to Stressors in the Sea Bass. In: Biology of European Sea Bass, pp: 374-400. Ed. By F. Javier Sánchez Vázquez and José A. Muñoz-Cueto. CRC Press. Boca Raton, Florida
2016. Schreck, C.B., Tort, L., Farrell, A.T. and Brauner, C. J (2016). Biology of stress in fish. Fish Physiology Series vol. 35. Academic Press-Elsevier. 590. Ed by: C.B. Schreck, L. Tort, Farrell, T. and Brauner, C. pp. ISBN: 978-0-12-802728-8.
2016. Schreck, C.B. and Tort, L. (2016). The concept of stress in fish. In: Biology of stress in fish. Fish Physiology Series vol. 35. Ed by Schreck, C.B., Tort, L., Farrell, A.T. and Brauner, C. J. Academic Press-Elsevier. ISBN: 978-0-12-802728-8, pp 2-34.
2016. Yada, T. and Tort, L. (2016). Stress and Disease Resistance: Immune System and immunoendocrine Interactions. In: Schreck, C.B., Tort, L., Farrell, A.T. and Brauner, C. J. Biology of stress in fish. Fish Physiology Series vol. 35. Academic Press-Elsevier. 590 pp. ISBN: 978-0-12-802728-8, pp. 366-405.
2017. Immunostimulant diets and oral vaccination in fish. Eva Vallejos-Vidal, Felipe E. Reyes-López,Simon Mackenzie. In: “Diagnosis and Control of Diseases of Fish and Shellfish”. Wiley.
Ali Reza Khansari, Joan Carles Balasch, Felipe E. Reyes-López and Lluís Tort (2017). Stressing the inflammatory network: immuno-endocrine responses to allostatic load in fish. J. Mar. Sci. Technol. In Press
2009. Combined effects of copper and bacterial lipopolysaccharide on immune and oxidative stress responses in rainbow trout macrophages. 11th International congress of the international society for developmental and comparative immunology. Prague (Czech Republic), 28 June-4 July. Teles M, Boltaña S, Mackenzie S., Tort L.
2009. Modulation of steroidogenic and immune functions in head kidney cells of gilthead sea bream stimulated with a chemical stressor. 7th Congress AIEC. Porto, Portugal. Teles M., Castillo J., Tort L.
2009. Immuno-endocrine interactions in the head kidney of fish subjected to stressors. 7th Congress AIEC. Porto, Portugal. Tort L., Teles M., Castillo J.
2009. Molecular and genomic responses to immune challenges in fish. World Aquaculture 2009. Veracruz, México. September. Tort L., Doñate C., Balasch JC, Roher N., Mackenzie S.
2009. Replacement of diet fish oil by vegetable oils affects expression of proinflammatory cytokines Tumor Necrosis Factor and Interleukin-1B genes in gilthead sea bream Sparus aurata after exposure to the bacterial pathogen Photobacterium damsela sp. Piscicida. World Aquaculture. Veracruz, México. September. Montero D., Mathlouthi F., Negrin D., Tort L., Afonso JM., Izquierdo M.
2010. Cloning of C3 in gilthead sea bream (Sparus aurata) and in European sea bass (Dicentrarchus labrax) and its differential expression after crowding plus pathogenic challenge. First EOFFI symposium. Viterbo (Italy), 23-27 May. Mauri I, Roher N, Romero A, Béjar J, Álvarez MC, Mackenzie S, Tort L.
2010. Improvement of aquaculture production by the use of biotechnological tools (AQUAGENOMICS). Aquaculture Europe 2010. Porto (Portugal), 5-8 October. Novoa B, Martínez P, Piferrer F, Mackenzie S, Planas JV, Morán F, Toranzo AE, Mulero V, Sanchez FJ, Estepa A, Coll J, Tort L, Yufera M, Pérez J, Zanuy S, Cerdá JM, Toro MA, Rejón MR, Figueras A.
2010. Transcriptomic and inflammatory response of cell-wall Peptidoglycan from gram-negative bacteria over fish macrophages. EOFFI meeting. Viterbo Italia. Boltaña, S., Roher, N, Tort, L. and Mackenzie, S
2010. Differential isoform expression after crowding plus pathogenic challenge in gilthead sea bream Sparus aurata and in European sea bass Dicentrarchus labrax. Fish Biology Congress. American Fisheries Society. Barcelona. Mauri I., Roher N., MacKenzie S, Tort L.
2010. Expression of glucocorticoid receptor gene in different tissues of sea bream and its relationship with classical physiological response to chronic stressors. Fish Biology Congress. American Fisheries Society. Barcelona. Teles M., Boltaña S., Pacheco M., Santos M.A., Mackenzie S, Tort L.
2010. The role of dietary fatty acids as modulators of fish stress response and welfare. Fish Biology Congress. American Fisheries Society. Barcelona. Montero D., Ganga R., Caballero MJ., Negrín D, Benítez-Santana T, Tort L, Afonso JM, Izquierdo MS.
2012. Study of interrenal function in rainbow trout under stress conditions. 10th International Congress on the Biology of fish. American Fisheries Soc. Physiology section. Madison, WI, USA 15-19 July. Fierro C, Santa-Cruz MC, Tridico R, Tort L.
2012. High plasma cortisol levels induce transcriptional changes in the organs of rainbow trout. 10th International Congress on the Biology of fish. American Fisheries Soc. Physiology section. Madison, WI, USA 15-19 July. Cortés R, Teles M, Trídico R, Tort L.
2012. Cortisol implants induce changes in complement and lysozyme levels in plasma, as well as in the transcription of immune-related genes in rainbow trout. International Congress on Global Advances on Advanced Biology. Barcelona 9-12. Cortés R, Teles M, Trídico R, Tort L.
2012. Stress and Immune response in sea bream (Sparus aurata) after experimental treatment with LPS of A. Salmonicida and L. Anguillarum. 10th International Congress on the Biology of fish. American Fisheries Soc. Physiology section. Madison, WI, USA 15-19 July. Tridico R, Boltaña S, Fierro-Castro C, Teles M, Cortes R, MacKenzie S, Tort L.
2012. Stress effect on the interrenal cells function in rainbow trout (Oncorhynchus mykiss). International Congress on Global Advances on Advanced Biology. Barcelona 9-12 July. Fierro-Castro C, Santa-Cruz MC, Tridico R, Martin L, Teles M, Tort L.
2014. Effects of cortisol implants on innate immune genes and corticosteroid receptor genes in rainbow trout. XI International Congress on the Biology of Fish. Edinburgh 3-7 August. American Fisheries Society. Physiology Section. Teles M, Fierro-Castro C, Tridico R, Cortes R, Tort L.
2014. The Response to Stressors in the Sea Bass. In: Biology of European Sea Bass, pp: 374-400. Ed. F. Javier Sánchez Vázquez and José A. Muñoz-Cueto. CRC Press. Boca Raton, Florida. Tort L, Rotllant J, Pavlidis M, Montero D, Terova G. Tort L, Rotllant J, Pavlidis M, Montero D, Terova G.
2014. Methionine and tryptophan differentially regulate the European sea bass Dicentrarchus labrax inflammatory response. Aquaculture Europe Congress. San Sebastian, 15-17 October. Azeredo R, Machado M, Díaz-Rosales P, Afonso A, Fierro-Castro C, Reyes-Lopez F, Tort L , Gesto M, Conde-Sieira M, Míguez MJ, Soengas JL, Peres H, Oliva-Teles A, Costas B.
2014. Differential gene response after repeated stress in proactive and reactive zebrafish. Aquaculture Europe Congress. San Sebastian, 15-17 October. Carrillo E, Khansari A, Reyes F, Parra D, Tort L.
2015. Rita Azeredo, Jaume Perez-Sanchez, Ariadna Sitja-Bobadilla, Belen Fouz, Lluis Tort,Aires Oliva-Teles, Benjamin Costas. Dietary arginine compromises innate immunity and decreases disease resitance in European Sea bass Dicentrarchus labrax. Aquaculture Europe. 20-23 Oct. 2015. Rotterdam (Netherlands).
2015. Daniel Montero, Genciana Terova, Simona Rimoldi, Luis Tort, Davinia Negrin, Maria Jesus Zamorano, Marisol Izquierdo. Modulation of adrenocorictropin hormone (ACTH)-induced expression of stress related genes by PUFA and interrenal cells from European sea bass Dicentrarchus labrax. Aquaculture Europe. 20-23 Oct. 2015. Rotterdam (Netherlands).
2015. Ali Reza Khansari , David Parra, Lluis Tort, Felipe E. Reyes-López. Endrocrine-immune system interaction after hormone and pathogen administration in primary head kidney cell culture: a comparative response between rainbow trout (Oncorhynchus mykiss) and gilthead sea bream (Sparus aurata). Aquaculture Europe. 20-23 Oct. 2015. Rotterdam (Netherlands).
2016. Ali R. Khansari, Felipe E. Reyes-López, David Parra and Lluís Tort. Comparative in vitro study of the effect of stress hormones on the cytokine expression profile of head kidney cells in in rainbow trout (Oncorhynchus mykiss) and seabream (Sparus aurata). XII Fish Biology Congress. American Fisheries Society, Physiology Section. San Marcos Texas 12-16 June 2016.
2016. C. Fierro-Castro, M. Carmen Santa-Cruz, M. Hernández-Sánchez, M. Teles, L. Tort. Analysis of steroidogenic pathway key transcripts in interrenal cells isolated by laser microdissection (LMD) in stressed rainbow trout. XII Fish Biology Congress. American Fisheries Society, Physiology Section. San Marcos Texas 12-16 June 2016.
2016. Teles, M. Fierro-Castro, C. Tort L., Oliveira M. Evaluation of gemfibrozil effects in a marine fish (Sparus aurata) combining ecotoxicogenomic tools with conventional endocrine and biochemical biomarkers. 8th International Symposium on fish endocrinology. Göteborg 28 June- 2 July 2016.
2016. Fierro-Castro, C. Carmen Santa-Cruz, M. Hernández-Sánchez, M. Teles, M. Tort. Analysis of steroidogenic pathway key transcripts in interrenal cells of rainbow trout (Oncorhynchus mykiss). 8th International Symposium on Fish Endocrinology. Göteborg 28 June- 2 July 2016.
2017. Valérie Cornet, Abderrahim Ouaach, Robert SNM Mandiki, Aline Ferain, Mélusine Van Larebeke, Benjamin Lemaire, Felipe E. Reyes López, Lluis Tort and Patrick Kestemont (2017). Influence of Q3 fatty acid enriched diets on sensitivity to heavy metal exposure and pathogen inffection in rainbow trout juveniles. 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19). Matsuyama, Japan, 30 June-3 July.
2017. Khansari, A.R., F. Reyes-López, D.Parra, L. Tort. Modulatory effect of stress hormones on the cytokine response of trout and sea bream head kidney tissue after exposure to Vibrio anguillarum. European Association of Fish Pathologists. 4-7 September. Belfast 2017.
2017. Brandts, I., M. Teles, A.P. Gonçalves, A. Barreto, M.A. Martins, L. Tort and M.Oliveira. Combined effects of nanoplastic particles and carbamazepine on the mussel Mytilus galloprovincialis. Aquaculture Europe 2017 October 17-20, Dubrovnik, Croatia.
2017. Khansari, Ali Reza, Eva Vallejos, David Parra, Camino Fierro, Joan Carles Balasch, Felipe Reyes-Lopez, Lluis Tort. Comparative immune response of rainbow trout (Oncorhynchus mykiss) and gilthead seabream (Sparus aurata) mucosal surfaces following acute handling stress and Vibrio anguillarum exposure. Aquaculture Europe 2017. October 17-20, Dubrovnik, Croatia.
2012. Tort L. The response to stressors in fish. An interactive integration involving all regulatory systems. 10th International Congress on the Biology of fish. American Fisheries Soc. Physiology section. Main Lecture. Madison, WI, USA 15-19 July.
2015. L. Tort. Stress and immune competence in fish. 6 International Symposium of Nutrition and Health of fish. 7-9 October 2015. Botucatu, Sao Paulo. Brazil. Invited key-note
2015. L. Tort. Interaction between physiological systems in fish under stress situations. XIII Reunión Annual Sociedad Chilena de Inmunología. Invited key-note. 23-25 Nov. Puerto Varas. Chile. Invited key-note.
2015. Felipe E. Reyes-López. Evaluating the immune response of Atlantic salmon (Salmo salar) against infectious necrosis pancreatic virus (IPNV) from the functional genomics perspective. XIII Reunión Annual Sociedad Chilena de Inmunología. Invited key-note. November 23-25. Puerto Varas. Chile.
2011. Sebastián Boltaña Harms. Universidad Autónoma de Barcelona. Molecular characterization of the underlying mechanisms of pathogen-associated molecular pattern (PAMP) recognition in fish. Supervisors Mackenzie S, Tort L.
2012. Israel Mauri Baños. UAB. Isra Stocked and locked. Effects of intensive aquaculture practices on immune system of gilthead sea bream (Sparus aurata) and European sea bass (Dicentrarchus labrax). Supervisors Tort L, Roher N.
2013. Reynaldo Vargas Vargas. Contribución de la personalidad en la variación fenotípica y su impacto sobre la biología del pez cebra Danio rerio. Supervisors Rey S, Mackenzie S.
2015. Eva Vallejos Vidal. Molecular Regulation of the Immune Function in the Gills of Gilthead sea bream (Sparus aurata) fed with immunostimulant diets. Supervisors S. Mackenzie. University tutor: L. Tort
2017. AliRheza Khansari. Comparative study of immune suppression in different fish species. Supervisors Tort L, Reyes F. (submitted 2017)
Alejandra Godino. Estudio de los requerimientos de proteína bruta y harina de pescado respecto a los parámetros productivos en Cilus gilberti, corvina autóctona de Chile and Perú. June 2015. Supervisor: Lluis Tort.
2011. Lluís Tort, Simon Mackenzie, Antonio Figueras. Aplicaciones de la genética y la genómica en el bienestar animal. Jornada sobre bienestar animal en Acuicultura. Madrid.
2012. Lluís Tort. The response to stressors in fish. An interactive integration involving all regulatory systems. Oregon State Univ.
2013. II Workshop in Nanomedicine de la UAB (8 de October 2013- Hotel Campus UAB (Cerdanyola del Valles). Roher N, Tort L.
2014. Lluís Tort. Relevant challenges in Aquaculture, the fastest growing agroindustry. Seminar MATGAS (CSIC-Air Products-UAB). 19 sept. 2014
2015. Lluis Tort. The stress response and their indicators. Univ. Aveiro 27 May 2015
UE. COPEWELL. KBBE.2010.1.2-07 - Understanding of the basic mechanisms involved in coping strategies of fish towards improvement of welfare
TARGETFISH. Targeted disease prophylaxis in European fish farming. Grant Agreement No. 311993) under the 7th Framework Programme for Research and Technological Development
Aquatic systems under multiple Stress: a new paradigm integrating aquaculture and ecotoxicology research (AquaStress). Research project P7/31 (Research action P7). Belgium Government
PERFORMFISH. Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain”. European Commission’s Horizon 2020 funding programme, grant number 727610.
CENAVISA (Reus, Tarragona) for the determination of the immune response of fish to anti-stress treatments.